2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-106207
    Celivarone 401925-43-7 98%
    Celivarone (SSR149744C) is a orally active noniodinated benzofuran derivative with antiarrhythmic properties. Celivarone has the potential for atrial fibrillation and in ventricular arrhythmias research.
    Celivarone
  • HY-106234
    ZP 120C 383123-18-0 98%
    ZP 120C is a potent and partial ORL1 receptor agonist. ZP 120C inhibits electrically induced contraction. ZP 120C can be used in the research of hyponatremia/hypokalemia.
    ZP 120C
  • HY-106337
    SB 247083 188186-61-0 98%
    SB 247083 is a selective, competitive and orally active endothelin-A receptor antagonist with a Ki of 0.41 nM. SB 247083 shows a Ki of 467 nM to endothelin-B receptor. SB 247083 shows a Kb of 3.5 nM for ET-1-induced contraction of rat aorta. SB 247083 can be used for the research of cardiovascular disease.
    SB 247083
  • HY-106394
    TP-9201 138297-15-1 98%
    TP-9201 is a platelet glycoprotein (GP) IIb/IIIa receptor antagonist. TP-9201 inhibits the interaction between GPIIb/IIIa and fibrinogen, thereby suppressing platelet aggregation. TP-9201 exhibits similar inhibitory activity on adenosine diphosphate (ADP) (HY-W010918)-induced platelet aggregation in humans, baboons, and dogs (IC50 = 1-3 μM), while showing lower activity in rabbits (IC50 = 45 μM) and rats (IC50 = 20 μM). TP-9201can be used in studies related to the prevention of rethrombosis after arterial thrombolysis.
    TP-9201
  • HY-106398
    MED 27 104333-87-1
    MED 27 is an inhibitor of thromboxane synthase and thromboxane A2 receptors. MED 27 can inhibit rat platelet aggregation at doses much lower than that of acetylsalicylic acid (HY-14654).
    MED 27
  • HY-106404
    RPR 130737 205054-36-0 98%
    RPR 130737 is a selective, potent and competitive inhibitor for factor Xa with a Ki of 2.4 nM. RPR 130737 shows selectivity of more than 1000-fold over thrombin, activated protein C, plasmin, tissue-plasminogen activator and trypsin. RPR 130737 can prolong plasma activated partial thromboplastin time and prothrombin time. RPR 130737 shows no effect on platelet aggregation. RPR 130737 can be used for the research of cardiovascular disease, such as thrombosis.
    RPR 130737
  • HY-106416
    Neldazosin 109713-79-3 98%
    Neldazosin is a potent alpha1-adrenoceptor antagonist.
    Neldazosin
  • HY-106427
    SA-13353 379262-36-9 98%
    SA-13353 is a TRPV1 agonist with cardioprotective effect. SA-13353 can be used for the research of cardiovascular disease .
    SA-13353
  • HY-106428
    Icrocaptide 169543-49-1 98%
    Icrocaptide (ITF1697) is a stable Lys-Pro-containing peptide that inhibits the intracellular Ca2+-dependent fusion of Weibel-Palade bodies with the plasma membrane. Icrocaptide exerts its activity at the early stages of endothelial activation and inhibits P-selectin and von Willebrand factor secretion. Icrocaptide can be used for the study of a variety of microvascular disorders.
    Icrocaptide
  • HY-106447
    Losulazine 72141-57-2 98%
    Losulazine is an antihypertensive agent acting by a sympatholytic mechanism. Losulazine's hypotensive activity depends on the presence of an intact, functional sympathetic nervous system.
    Losulazine
  • HY-106471
    Pildralazine 64000-73-3 98%
    Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model.
    Pildralazine
  • HY-106476
    Primidolol 67227-55-8 98%
    Primidolol (UK-11443), derived from Parmotrema perlatum, possesses antibacterial and antioxidant activities. Primidolol is also an orally active α/β Adrenergic Receptor blocker with antihypertensive activity. Primidolol can be used in research related to infections and cardiovascular diseases.
    Primidolol
  • HY-106499
    Sulfinalol 66264-77-5 98%
    Sulfinalol is an orally active β-adrenoceptor antagonist with direct vasodilator activity.
    Sulfinalol
  • HY-106523
    Nipradolol 81486-22-8 98%
    Nipradolol (KT-210; K-351) is a potent blocker of alpha-1-adrenergic receptors. Nipradolol inhibits the increase of intraocular pressure (IOP) in an albino rabbit model induced by Phenylephrine (HY-B0769). Nipradolo suppresses the noradrenaline (NA)-induced muscles contraction, also exhibits vasodilator activity on the dog coronary artery.
    Nipradolol
  • HY-106554
    Trimazosin 35795-16-5 98%
    Trimazosin is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenoceptors.
    Trimazosin
  • HY-106559
    Sorbinicate 6184-06-1 98%
    Sorbinicate, a derivative of nicotinic acid, exerts a favourable influence on blood rheology and platelet function.
    Sorbinicate
  • HY-10655A
    Palosuran hydrochloride 2469274-58-4 98.67%
    Palosuran hydrochloride (ACT-058362 hydrochloride) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran hydrochloride can improves pancreatic and renal function in diabetic rats.
    Palosuran hydrochloride
  • HY-106561
    Tioclomarol 22619-35-8 98%
    Tioclomarol, a coumarin anticoagulant, is a vitamin K antagonist.
    Tioclomarol
  • HY-106565
    Meproscillarin 33396-37-1 98%
    Meproscillarin (Methylproscillaridin) is a glycoside. Meproscillarin can be used for research of heart failure.
    Meproscillarin
  • HY-106580
    Plafibride 63394-05-8 98%
    Plafibride (ITA 104) is an orally active hypolipemic, platelet aggregation inhibitor.
    Plafibride
Cat. No. Product Name / Synonyms Application Reactivity